Ghrelin Stimulates GH But Not Food Intake in Arcuate Nucleus Ablated Rats

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Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats.

Ghrelin, an endogenous ligand for the GH secretagogue receptor 1a (GHS-R(1a)), was originally purified from the rat stomach. Ghrelin mRNA and peptide have also been detected in the hypothalamus and pituitary. Ghrelin is a novel acylated peptide that regulates GH release and energy metabolism. GHS-R(1a) mRNA is expressed in the pituitary gland as well as in several areas of the brain including t...

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Antagonism between Ghrelin / GH secretagogues and somatostatin in arcuate and periventricular nuclei in prepubertal female rats

Combined growth hormone-releasing hormone (GHRH) and growth hormone secretagogues (GHS) have been used alone or in combination with somatostatin (SRIF) to study the pituitary growth hormone (GH) reserve in adults with GH deficiency, but not in children, owing to the possible adverse effects of these treatments. The study aimed to assess the response of the arcuate and periventricular hypothalam...

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Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

OBJECTIVE Glucagon-like peptide-1 (GLP-1) promotes glucose homeostasis through regulation of islet hormone secretion, as well as hepatic and gastric function. Because GLP-1 is also synthesized in the brain, where it regulates food intake, we hypothesized that the central GLP-1 system regulates glucose tolerance as well. RESEARCH DESIGN AND METHODS We used glucose tolerance tests and hyperinsu...

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A Natural Variant of Obestatin, Q90L, Inhibits Ghrelin's Action on Food Intake and GH Secretion and Targets NPY and GHRH Neurons in Mice

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Arcuate nucleus glucokinase and dietary glucose intake

Glucose is the primary fuel for the brain. It has been proposed that the brain senses glucose, and promotes eating behaviours when levels are low. A system regulating glucose intake, driven by hedonic responses generated in the limbic system, has been identified. A taste-independent mechanism within the CNS that promotes glucose intake has been postulated. Glucokinase is a member of the hexokin...

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ژورنال

عنوان ژورنال: Endocrinology

سال: 2002

ISSN: 0013-7227,1945-7170

DOI: 10.1210/en.2002-220268